Table 1 |
||
|
Central and peripheral sites of action of CB1 receptor antagonists and outcomes of the blockade of the endocannabinoid (EC) system. |
||
|
SITE OF ACTION |
MECHANISMS OF ACTION |
BLOCKADE OF EC SYSTEM EFFECTS |
|
|
||
|
Hypothalamic nuclei |
↓ food intake |
body weight waist circumference |
|
|
||
|
Adipose tissue |
↑ adiponectin ↓ lipogenesis |
dyslipidemia insulin resistance |
|
|
||
|
Skeletal muscle |
↑ glucose uptake |
insulin resistance |
|
|
||
|
Liver |
↓ lipogenesis |
dyslipidemia insulin resistance |
|
|
||
|
Gastrointestinal tract |
↑ satiety signals |
body weight waist circumference |
|
|
||
|
Tibiriça Diabetology & Metabolic Syndrome 2010 2:5 doi:10.1186/1758-5996-2-5 |
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