Table 1

Histopathological findings in insulin-induced circumscript lipoatrophy, as reported in the literature.

Previous reports, author

Reeves [1]

Jermendy [5]

Lopez [10]

Chantelau [3]

present case

cases,n

5

1

4

1

Skin:

immunofluorescence staining*

positive

negative

not analysed

negative

not analysed

mononuclear cell infiltration

mild

none

not analysed

mild

not analysed

Subcutaneous tissue:

fat tissue atrophy

present

absent?

present

present

present

focal fibrosis

absent?

absent?

present

present

present

lipoblast-like adipocytes

absent

present

absent

absent

absent

capillary proliferation

absent

present

absent

absent

absent

immunofluorescence staining*

not analysed

not analysed

negative

negative

not analysed

lymphocyte infiltration

absent

not analysed

mild

mild

not analysed

eosinophils infiltration

absent

not analysed

present

absent

not analysed

mast cells infiltration

absent

not analysed

present

absent

not analysed

*for IgG, IgA, IgM, C1, C3, and fibrin, or amyloid, respectively

Chantelau et al. Diabetology & Metabolic Syndrome 2011 3:33   doi:10.1186/1758-5996-3-33