Correlation of circulating C1q and C1q-binding adiponectin concentrations with aging in males: a preliminary report
1 Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
2 Kishida Clinic, Osaka 560-0021, Japan
3 Department of Research and Development, Diagnostic Division, Otsuka Pharmaceutical Co., Ltd, Tokushima 771-0195, Japan
4 Hitachi, Ltd. Hitachi Health Care Center, Hitachi, Ibaraki, 317-0076, Japan
5 Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
Diabetology & Metabolic Syndrome 2013, 5:17 doi:10.1186/1758-5996-5-17Published: 27 March 2013
Atherosclerosis is an age-related disease. Adiponectin and C1q form a protein complex in human blood, and that serum C1q and C1q-binding adiponectin (C1q-APN) concentrations can be measured. We investigated circulating C1q and C1q-APN levels in Japanese men including elderly men.
The study subjects were 509 Japanese men including elderly men. Serum levels of total adiponectin (Total-APN), high-molecular weight-adiponectin (HMW-APN), C1q-APN and C1q were measured by enzyme-linked immunosorbent assay. Total-APN, HMW-APN and C1q-APN, but not C1q, correlated significantly and positively with aging (r=0.26, r=0.24, r=0.17, p<0.01, respectively). The HMW-APN/Total-APN ratio correlated significantly and positively with aging (r=0.14, p<0.01). The C1q-APN/Total-APN ratio and C1q-APN/HMW-APN ratio correlated significantly and negatively with aging (r=−0.17, p<0.01, r=−0.12, p=0.01). C1q-APN/C1q correlated significantly and positively with aging (r=0.09, p=0.03). Multiple regression analysis identified age and body mass index as significant determinants of C1q-APN.
The present study demonstrates that serum HMW-APN, C1q-APN, and Total-APN, but not C1q, correlated positively with aging. These preliminary results could form the basis for future research.
Clinical Trial Registration Number: UMIN000004318